Anti - Microbial Plasma Membrane Activity of Daptomycin and Pantoyl Lactone against Streptococcus Equi

نویسنده

  • Zidan A. Bashir
چکیده

In this study, the ability of two antibiotics daptomycin and pantoyl lactone to inhibit growth of horse originated pathogen Streptococcus equi by disrupting plasma membrane of the bacterium was investigated using agar diffusion and micro tube dilution methods. The results obtained from this study indicated that daptomycin was more effective in inhibiting the growth of the pathogen in vitro than the second antibiotics. The 3 tested strains were susceptible to daptomycin but completely resistant to pantoyl lactone. Hence, daptomycin therefore tends to be potent for treating horse infections caused by this pathogen.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

A review on the inhibitory potential of Nigella sativa against pathogenic and toxigenic fungi

Nigella sativa (N. sativa) grows in various parts of the world, particularly in Iran. It has been traditionally used as a folk remedy to treat a number of diseases. The seeds of this plant contain moisture, proteins, carbohydrates, crude fiber, alkaloids, saponins, ash, fixed oils and essential oil. The major components of the essential oil are thymoquinone, p-cymene, trans-anethole, 2-methyl-5...

متن کامل

In vitro Evaluation of the antibacterial activity of Platelet-rich Plasma against Selected Oral and Periodontal Pathogens

Background: Despite the availability of a wide range of antibiotics, bacterial infections are among important challenges for the healthcare system. Therefore, the introduction of new antimicrobial preparations such as platelet-rich plasma (PRP) could be suggested theoretically as a preventive measure for bacterial infections. We aimed to evaluate the in vitro antibacterial activity of PRP again...

متن کامل

Enterococcus faecalis and pathogenic streptococci inactivate daptomycin by releasing phospholipids

Daptomycin is a lipopeptide antibiotic with activity against Gram-positive bacteria. We showed previously that Staphylococcus aureus can survive daptomycin exposure by releasing membrane phospholipids that inactivate the antibiotic. To determine whether other pathogens possess this defence mechanism, phospholipid release and daptomycin activity were measured after incubation of Staphylococcus e...

متن کامل

Ketopantoyl lactone and ketopantoic acid reductases. Characterization of the reactions and purification of two forms of ketopantoyl lactone reductase.

Spectral and chromatographic data as well as methods for synthesis of 14C-labeled ketopantoic acid, ketopantoyl lactone, pantoic acid, and pantoyl lactone are presented. The products of ketopantoic acid and ketopantoyl lactone reductases were characterized as pantoic acid and pantoyl lactone, respectively. Unlike pantoyl lactone, ketopantoyl lactone spontaneously hydrolyzes and has a half-life ...

متن کامل

IgG Endopeptidase SeMac does not Inhibit Opsonophagocytosis of Streptococcus equi Subspecies equi by Horse Polymorphonuclear Leukocytes

The secreted Mac protein made by group A Streptococcus (GAS) inhibits opsonophagocytosis of GAS by human polymorphonuclear leukocytes (PMNs). This protein also has the endopeptidase activity against human immunoglobulin G (IgG), and the Cys94, His262 and Asp284 are critical for the enzymatic activity. The horse pathogen Streptococcus equi subspecies equi produces a homologue of Mac (SeMac). SeM...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2013